I'm surprised this hasn't become a fad

[johnjohn320]

Originally posted by: Amused

Originally posted by: johnjohn320

Originally posted by: Amused

Originally posted by: ElFenix

Originally posted by: Amused
http://www.ncbi.nlm.nih.gov/entrez/quer...PubMed&list_uids=1519610&dopt=Abstract

Two college students who developed reversible acute deterioration in renal function following binge drinking of beer and the use of nonsteroidal antiinflammatory drugs (NSAIDs) are reported. Both patients presented with back and flank pain with muscle tenderness, but showed no evidence of overt rhabdomyolysis. The first case had marked renal failure, with a peak serum creatinine reaching 575 mumol/L (6.5 mg/dL), and acute tubular necrosis was documented by renal biopsy. The second case had only modest elevation in serum creatinine, and renal function rapidly improved on rehydration. The contribution of the potential muscle damage associated with alcohol ingestion to the changes in renal function in these two cases is not clear. However, the major mechanism for the acute renal failure was thought to be related to inhibition of renal prostaglandin synthesis in the face of compromised renal hemodynamics secondary to alcohol-induced volume depletion.

what?

What part didn't you understand?

You must've written excellent essays in school if you feel that the above is clear and obvious to the average reader.

Wow, OK, I'll try to break it down for you:

Two college students who developed reversible acute deterioration in renal function following binge drinking of beer and the use of nonsteroidal antiinflammatory drugs (NSAIDs) are reported.

They hurt their kidneys, but it was reversable.

Both patients presented with back and flank pain with muscle tenderness, but showed no evidence of overt rhabdomyolysis.

They had back and side pain, but no evidence of a disease called Rhabdomyolysis.

The first case had marked renal failure, with a peak serum creatinine reaching 575 mumol/L (6.5 mg/dL), and acute tubular necrosis was documented by renal biopsy.

His kidneys were fscked

The second case had only modest elevation in serum creatinine, and renal function rapidly improved on rehydration.

His kidneys were not so fscked

The contribution of the potential muscle damage associated with alcohol ingestion to the changes in renal function in these two cases is not clear. However, the major mechanism for the acute renal failure was thought to be related to inhibition of renal prostaglandin synthesis in the face of compromised renal hemodynamics secondary to alcohol-induced volume depletion.

The combination of ibuprofen and alcohol shut their kidneys down.

Thanks for the breakdown, even though you had to do so with an attitude. I guess words like "rhabdomyolysis, serum creatinine, acute tubular necrosis, renal prostaglandin synthesis, & hemodynamics" were not yet in my meager vocabulary. I'll get on that, and in the meantime remember how much smarter people on the internet (like you) obviously are than me.

 

[2Xtreme21]

Probably the same reason drinking gasoline hasn't become a fad. IT KILLS! (Though I'm sure one could get a nasty buzz off it.)

 

[Juddog]

Originally posted by: johnjohn320
Haha, I love how everybody's taking this so seriously. Look, I don't condone it, and I never did it intentionally. I just ended up learning a lesson about a year ago when I was on a heavy dose of Ib. I was only commenting that I found it interesting that there doesn't seem to be a flock of people who do this on purpose...sure it's unsafe, but we're talking about people who aren't concerned with their health, they want to get fscked up.

People take it seriously because of the risk of someone reading the initial thread and telling his friend "yo I hear you can get rocked if you do a bunch of advil before you drink dude!"

I believe this is why some of the responses are so serious - we're basically saying, if you are thinking of doing it - don't.

 

[Amused]

Originally posted by: johnjohn320

Originally posted by: Amused

Originally posted by: johnjohn320

Originally posted by: Amused

Originally posted by: ElFenix

Originally posted by: Amused
http://www.ncbi.nlm.nih.gov/entrez/quer...PubMed&list_uids=1519610&dopt=Abstract

Two college students who developed reversible acute deterioration in renal function following binge drinking of beer and the use of nonsteroidal antiinflammatory drugs (NSAIDs) are reported. Both patients presented with back and flank pain with muscle tenderness, but showed no evidence of overt rhabdomyolysis. The first case had marked renal failure, with a peak serum creatinine reaching 575 mumol/L (6.5 mg/dL), and acute tubular necrosis was documented by renal biopsy. The second case had only modest elevation in serum creatinine, and renal function rapidly improved on rehydration. The contribution of the potential muscle damage associated with alcohol ingestion to the changes in renal function in these two cases is not clear. However, the major mechanism for the acute renal failure was thought to be related to inhibition of renal prostaglandin synthesis in the face of compromised renal hemodynamics secondary to alcohol-induced volume depletion.

what?

What part didn't you understand?

You must've written excellent essays in school if you feel that the above is clear and obvious to the average reader.

Wow, OK, I'll try to break it down for you:

Two college students who developed reversible acute deterioration in renal function following binge drinking of beer and the use of nonsteroidal antiinflammatory drugs (NSAIDs) are reported.

They hurt their kidneys, but it was reversable.

Both patients presented with back and flank pain with muscle tenderness, but showed no evidence of overt rhabdomyolysis.

They had back and side pain, but no evidence of a disease called Rhabdomyolysis.

The first case had marked renal failure, with a peak serum creatinine reaching 575 mumol/L (6.5 mg/dL), and acute tubular necrosis was documented by renal biopsy.

His kidneys were fscked

The second case had only modest elevation in serum creatinine, and renal function rapidly improved on rehydration.

His kidneys were not so fscked

The contribution of the potential muscle damage associated with alcohol ingestion to the changes in renal function in these two cases is not clear. However, the major mechanism for the acute renal failure was thought to be related to inhibition of renal prostaglandin synthesis in the face of compromised renal hemodynamics secondary to alcohol-induced volume depletion.

The combination of ibuprofen and alcohol shut their kidneys down.

Thanks for the breakdown, even though you had to do so with an attitude. I guess words like "rhabdomyolysis, serum creatinine, acute tubular necrosis, renal prostaglandin synthesis, & hemodynamics" were not yet in my meager vocabulary. I'll get on that, and in the meantime remember how much smarter people on the internet (like you) obviously are than me.

Wow.

I'm not smarter than you. But when I see a word or phrase I don't understand I use this brilliant invention called "Google" to look it up.

Creatinine is a breakdown product of creatine, which is an important part of muscle. A serum creatinine test measures the amount of creatinine in the blood.

Acute tubular necrosis is a kidney disorder involving damage to the renal tubule cells, resulting in acute kidney failure.

Changes in renal function are due to inhibition of renal prostaglandin synthesis, which increase renal blood flow and maintain normal renal function. Hemodynamics (literally "blood dynamics") is merely the properties of that blood flow.

I found all that on google in less than 3 minutes.

 

[dug777]

Just drink more?