Rice started learning French, music, figure skating and ballet at age three.[12] At age 15, she began classes with the goal of becoming a concert pianist. Her plans changed when she realized that she did not play well enough to support herself through music alone.[13] While Rice is not a professional pianist, she still practices often and plays with a chamber music group. Rice made use of her pianist training to accompany cellist Yo-Yo Ma for Brahms's Violin Sonata in D Minor at Constitution Hall in April 2002 for the National Medal of Arts Awards.[14]
Rice graduated from St. Mary's Academy in 1970. In 1974, at age 19, Rice earned her B.A. in political science, Phi Beta Kappa, from the University of Denver. In 1975, she obtained her Master's Degree in political science from the University of Notre Dame. She first worked in the State Department in 1977, during the Carter administration, as an intern in the Bureau of Educational and Cultural Affairs. In 1981, at the age of 26, she received her Ph.D. in Political Science from the Graduate School of International Studies at Denver.
Rice was hired by Stanford University as an Assistant Professor in Political Science (1981?1987). She was granted tenure and promoted, first to Associate Professor (1987?1993), and then to Provost, the chief budget and academic officer of the university (1993?1999), and full Professor (1993?present).[19] Rice was the first female, first minority, and youngest Provost at Stanford.[20] She was also named a Senior Fellow of the Institute for International Studies, and a Senior Fellow (by courtesy) of the Hoover Institution. She was a specialist on the former Soviet Union and gave lectures on the subject for the Berkeley-Stanford joint program led by UC Berkeley Professor George Breslauer in the mid-1980s.
As Stanford's Provost, Rice was responsible for managing the university's multi-billion dollar budget. The school at that time was running a deficit of $20 million. When Rice took office, she promised that the budget deficit would be balanced within "two years." Coit Blacker, Stanford's deputy director of the Institute for International Studies, said there "was a sort of conventional wisdom that said it couldn't be done ... that [the deficit] was structural, that we just had to live with it." Two years later, Rice announced that the deficit been eliminated and the university was holding a record surplus of over $14.5 million.[22]
In 1986, while an international affairs fellow of the Council on Foreign Relations, Rice served as Special Assistant to the Director of the Joint Chiefs of Staff.
From 1989 through March 1991 (the period of the fall of Berlin Wall and the final days of the Soviet Union), she served in President George H.W. Bush's administration as Director, and then Senior Director, of Soviet and East European Affairs in the National Security Council, and a Special Assistant to the President for National Security Affairs. In this position, Rice helped develop Bush's and Secretary of State James Baker's policies in favor of German reunification. She impressed Bush, who later introduced her to Soviet leader Mikhail Gorbachev as the one who "tells me everything I know about the Soviet Union."[26]