- Mar 27, 2012
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Sodium naproxen.
if i take some protein powder would that increase the toxicity threshold of NAPQI?amino acid glutathione
Ibuprofen is probably better for muscular and soft tissue inflammatory pain because of its role as an anti-inflammatory, whereas tylenol (paracetamol) is a general-purpose analgesic. Both have risks with use, but neither is as serious as a lot of doctors make out; it's interesting how much of an overreaction the medical community has had to use of ibuprofen because of the risk of peptic ulcers and nephrotoxicity.
That said, there is a risk to using NSAIDs (of which ibuprofen is one) for prolonged periods of time for pain relief; the risk of peptic ulcers is a real one. Using them for 1-2 weeks, however, is not going to cause much harm. It's really people who chronically use them for years and years at a time, 3 or 4 times a day.
With paracetamol, the major risk is NAPQI poisoning. Paracetamol is metabolized by the liver, and one of the minor metabolites is NAPQI. The body neutralizes NAPQI with the amino acid glutathione, but if too much is produced, the body runs out and the NAPQI builds up in the liver It is the most common cause of hepatotoxicity in the Western world, but if you follow the instructions on the packet when you take it you should be well under the limit required for overdose, even if you drink alcohol at the same time (and alcohol does decrease the threshold for toxicity). If you follow the instructions, you really have to be taking paracetamol for months at a time while having a remarkably poor diet to get liver failure.
So basically, use whichever works better for you.
Oh good. So I should be safe taking them at the first sign of a migraine which usually happens a couple times a week.
if i take some protein powder would that increase the toxicity threshold of NAPQI?
With paracetamol, the major risk is NAPQI poisoning. Paracetamol is metabolized by the liver, and one of the minor metabolites is NAPQI. The body neutralizes NAPQI with the amino acid glutathione, but if too much is produced, the body runs out and the NAPQI builds up in the liver It is the most common cause of hepatotoxicity in the Western world, but if you follow the instructions on the packet when you take it you should be well under the limit required for overdose, even if you drink alcohol at the same time (and alcohol does decrease the threshold for toxicity). If you follow the instructions, you really have to be taking paracetamol for months at a time while having a remarkably poor diet to get liver failure.
So basically, use whichever works better for you.
I believe the biggest problem with paracetamol/acetaminophen is that it's found in a lot of painkillers in combination with narcotics. Vicodin is the most obvious example. People take Vicodin, don't realize what's in it, and then take Tylenol with their Vicodin. That can get dangerous relatively quickly.
Yeah, that's a problem too. I'm pretty sure the instructions take that into account though. With the instructions you should be getting around 4g of paracetamol a day max. You really need around 15g for an acute overdose to cause real harm, or around 10g per day for prolonged periods.I believe the biggest problem with paracetamol/acetaminophen is that it's found in a lot of painkillers in combination with narcotics. Vicodin is the most obvious example. People take Vicodin, don't realize what's in it, and then take Tylenol with their Vicodin. That can get dangerous relatively quickly.