If this is some kind of bug I imagine it's bound to happen on any profile it's just that using a new one does rule out that when the bug hits, it only affects the active profile. Suppose I could try to redo my profile to see if it fixes the issue permanently, it only happens like once or twice a month so it will be a while before I know. I only have a couple extensions. Privacy Badger, ublock, Facebook container, h264ify (fixes some performance issues I was having with some Youtube videos in Linux) and duckduckgo privacy essentials.