It should run fine at that resolution.
AA in stalker is borked when HDR is enabled, so don't even bother playing with the settings. I found that the HDR was more a boon than the AA when playing at 1900x1200. Also, the environments are so dense that you probably will not notice the jaggies anyway.
As schneiderguy mentioned, you should get the latest Float32 shader mod.
I would also suggest just skipping over the default game experience, and go right ahead and mod the game for your first play-through.
Vanilla Stalker kind of ... blows. Find a realism mod, or toy with the Simbion mod. It might break some of the original storyline quests for you, but it's a much richer and challenging experience.