Evidence says no, thats why i keep saying play with your settings.
But if you wanna go the overclocking route i can give you the basics, different motherboards have different ways of overclocking and differing terminilogy somtimes, so you should google "overclocking with an Asus A8N E" Which i cant say im familiar with, i dont generally keep up with motherboards.
Right the first thing you should do, is go download
speedfan and
Prime 95 its called SP2004, but its the same thing. This will help you test your overclock to see if its stable.
1. Go into the BIOS, locate the FSB setting of your cpu, which should be in the "frequency & voltage control" menu or somthing with a similar name and the FSB is the setting you raise to overclock your mobo. You should also see a multiplier setting in there, this is how the end clock speed is derived. For example, your chip stock runs at 2.2ghz dosent it? that could be a multiplier of 10 and an FSB of 220, 220X10=2200mhz. so if you raised the FSB to 240 you would get 2400mhz, lowered the multiplier to 8 and left the FSB at 240 and you would get 8X240=1920mhz see? Raise the FSB about 100mhz at a time until it fails prime instantly, then lower the FSB until you can run prime stable for well 12 hours is a good amount of time.
2. The memory divider! This stops you from overclocking your ram, which there isnt much point in doing with an A64 system as it dosent need fast ram. Now i have no idea what the ratio's are about if your mobo has ratio settings, mine has settings that say DDR266 DDR 333 DDR 400 etc. At stock FSB your ram will be at DDR400, but if you overclock that FSB by 20mhz it will go up to somthing like DDR420, which isnt good for the ram since its only rated at DDR400 i assume, so what you do is drop it down to DDR333, and itll run at somthing like DDR353 with the overclock, which is fast enough and safe. Not that overclocking your rams not safe, it is, but it causes instability.
3. I dont think you really wanna mess with the voltages for now, as your CPU gets faster it needs more juice, some need more than others it depends, try overclocking it on the stock voltage first. Voltage changes are the only real thing that can fry a cpu. Your winchester is a 90nm cpu and its stock voltage is 1.4V, the safe range is probably 1.4-1.5V, i wouldnt go over 1.5. but some people have 1.6 and 1.65 and run without problems. But its a limit of mine with 90nm.
Thats a really basic guide to overclocking kinda based on what ive done on my rig. Use that "quick n dirty" guide too theres a lot of info in there, google can help you too, for example if you wanna know about the dividers specifically on your mobo just google "Asus A8N E memory divider". Its a pretty easy process.