Its variable with all kinds of factors, such as the compressor design, how much load it places on an engine will vary with the size and power of the engine. It can be a sizable differnce with a low powered 4 cyl engine and almost negligle with a large powerful engine, like a diesel truck engine. However the large engine usually also comes with a large vehicle and fuel economy is low with those vehicles anyway. It also depends on the outside temperatures and how long the compressor stays engaged. In extremely hot climates like the desert SW it can stay engaged almost continously during the summer in traffic conditions. As stated highway economy will be greater as cycle on times are shorter due to engine RPM and air flow across the condenser. Modern AC systems use lighter weight AC systems which help contribute to the greater econmomy, as well as swashplate designs as opposed to older piston designs. Freon types can affect efficiency as well. Altitude affects efficiency. Humidity affects efficiency. Running on Max Ac allows maximum efficiency as it allows interior air to be recirculated rather than cooling hotter outside air. With so many designs of AC systems, so many different vehicle applications, so many different driving conditions and terrain, weather conditions as well, the amount of efficiency is widely variable.