My brother did it for a while. He and the wife wanted to move away from Richmond (Va), and they found a house in Greenville, SC. For a while, my brother had to continue working his job in Richmond, until he found work locally in SC. It was about a 6-7 hour drive every Friday evening and Sunday evening. He hates his job in SC now, but he likes it better than not seeing his family during the week.
I used to have a 35 mile commute, but that's down to 10 miles now, and I am hoping to cut that to about 50 feet before too long. Commuting sucks.