That's what they are there for - mitigating interference with other wireless devices.
If it weren't a problem then you wouldn't have extra channels to play with, if playing with extra channels weren't the solution then you wouldn't have extra channels to play with.
Now the question as to why you are experiencing interference and needing to play with the channels...well that is going to depend 100% on your local environment (power lines, other wireless devices, neighbor turning on/off their vacuum cleaner, etc) and it would be purely fools luck if anyone here guessed correctly what the source of interference is in your local environment.
I had a wireless mouse once that would freak out whenever the neighbor was playing with his radio-controlled toy car. Took me a long time to figure that one out...but once I did I could 100% accurately expect my mouse to be useless whenever I'd hear him out there in the street (the car was gas powered, not electric) with that thing.