Yes and No. If you consider an older board solution, based on VIA chipsets, like BIOSTAR M7VKL,the sound is no good, the video SAVAGE 4 3D is no good either, you can play some games at 800x600, but Serious Sam would go at minimum resolution (640x480) and minimum quality with a DURON 800 and 196Mb of RAM.
But a modern board, based on VIA nForce chipsets, with exelent on-board sound, and a Gforce 2 mx, coupled with DDR RAM would do just fine!, I can't mention a non working game in that platform.