For years I have used the same partitioning scheme - it works for me:
Main drive (80 GB)
C:\ = Operating System
D:\ = Utilities and Misc related programs
E:\ = Corel Office Suite 2002 and related programs
F:\ = Communications and Internet
G:\= Graphics and related programs
H:\= Swap/Page file and temporary CD burning cache
Separate drives:
A:\= Standard Floppy Drive
B:\= LS-120 SuperDisk drive
I:\ = DVD\CD Player
J:\= External Firewire HDD - for all data in support of all of the above
K:\= Media Reader/Writer (Digital Camera)
L:\= External CDRW (USB 2.0)
All plays together in perfect harmony.