Dust? Inside a harddrive? I thought these devices were sealed & produced in rigorous clean-room environment?
Also, Blain - a bit disappointed, to tell the truth. I saw your name responding and honestly expected some kind of vaguely inappropriate joke about how he mounts his HDD. And with the drive orientation remark above - wow, just didn't take advantage, did you? Feeling ill?
If it's a new drive you're probably ok to mount it however you like. If you're worried about it being damaged due to a bump - if it takes a hit that will damage it, the damage will occur no matter how it's oriented in the case. I've only lost one drive to a bump in nearly 20 years of working on these things. That one was a freaking oops - bare drive slipped out of my fingers during file copy and fell 1 inch to desk surface. Wouldn't read or access at all immediately. Moral of the story: don't handle your drives while they're working.