Even though you have riding experience from teh past the CBR 600F4i is a lot of bike.
I wouldnt suggest it as its a supersport as a first bike.
If your under 21 (18 in some states) you will require the MSF course. I suggest taking it to get your reacquainted with riding on two wheels.
Then I would suggest one of these bikes:
Suzuki GS 500 - tad bit underpowered but solid bike very fun to ride. Easy to work on and mod. I have this one.
Suzuki SV 650 / SVS 650 - awesome engine and bike
Kawasaki Ninja 500 - bit more powerful than the GS, and got the plastic crotch rocket body.
Buell Blast 500 - single cylinder 37hp.. pretty powerful
Honda Nighhawk 750 - its not really a starter bike cause its quite powrful, but its a good bike for someone who has some experience.
Personally I would vouch for teh SVS 650 cause its a much nicer bike, and its quite a bit powerful. About 75hp from 650cc engine, unlike the 600cc supersports that have over 110hp for 600 cc.
dont worry about your weight the bike will still lug you around. I know a 250 pound guy 6'2" guy who rides a GS500 and still has no problems riding it.
TGG