Welcome to the forums.
At that resolution, you need to keep anti aliasing filtering down to a minimum if you want to maintain playable frame rates. I would opt for 4x MSAA, which I would then drop down to 2x Temporal AA (if the game supports it), and finally 2x MSAA. Always try to use in-game MSAA settings rather than CCC, except for Temporal AA.
I would also enable performance Adaptive AA in the driver. It will not give you much of a quality improvement, but it doesn't give much of a performance hit either, so use it when you can (remember that it only works in DX9 right now). Same thing with Gamma correction.
As far as other settings go, I like my texture filtering settings to be all at the highest quality, I believe it's called MipMap in CCC, no optimizations, 16x AF. I force those settings globally, the performance hit from higher quality texture filtering is minimal and the quality improvement is huge.
Thanks for the response, I appreciate it! However, one additional setting I would like to ask about is the AA filter (Box, Narrow Tent, Wide Tent, Edge Detect). Are any of those at a clear advantage over the others, or is it a fairly linear trade off between performance and IQ as you progress down the line?
Also, when you say "no optimizations" does that refer to Catalyst AI? If not, I ask if anyone has input on what Catalyst AI does and if it has any positive or negative impact.
Thanks again!
edit: Upon further research, it seems that it is a setting which tries to intelligently decide what textures to filter less or not at all to provide additional performance boost, though people have trouble telling if it actually does anything at all.
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