The second fan would be beneficial because the second fan would lower the amount of pressurization that the first would have to do. However the difference would not be great.
One thing that I had on my old case was a big ass fast blowhole (120mm high speed panaflow,105CFM) directly over the CPU. This actually caused the CPU fan to spin at 900RPM faster (4900 vs. 5800) because of the massive amount of airflow coming down on it. Depending on the ambient temperature (and the amount of dust that collected), and the CPU usage I would drop 5-15F when I switched on the blowholes (2x120mm, 2x60mm in the drive bays, about 200CFM total)