Heya,
By multiple drives, are you referring to RAID0? In general, you'll see a curve when it comes to scaling performance in RAID0. For two drives, it's nearly double, but not quite, for large file sustained transfers. But each drive you add to RAID decreases its access time, making it even worse for random small file access. RAID0 really is not that great for performance any more. It used to be all we really had. RAID0 is only good at large file transfer rates. You can short stroke an array to make it even faster and reduce access time, but if you do that you might as well just get an SSD and the SSD will still beat it in general use (IOPS, random small file read/writes, etc).
For example, my single SSD performs as well as two WD 640Gb 7200rpm drives in RAID0. But, my IOPS is multiple times higher than the HDD RAID0 array and my access time is near immeasurable whereas the RAID0 array's access time is like 12ms. Even when short stroked down to 128Gb in RAID0, my SSD beats the two drives in RAID0 in IOPS and access time.
If you're trying to get the best performance you can, you should get an SSD. If the price is keeping you away, well, you said multiple drives and the price of two drives is very close to that of an SSD. The only real advantage anymore is the capacity of HDDs.
NewEgg has a shell shocker going right now for a 64Gb SSD for $120 basically. It's a very good deal if you're looking or a good performance drive on a dime. It's not the best/fastest SSD out there, but it is still faster than RAID0 HDD arrays. The IOPS and access time simply smoke HDD's in comparison. Grab one if you've been waiting. It's a ridiculous price. Two of them in RAID0 themselves would be blistering for the cost.
If your sole use is for huge file transfers, stick with HDD in RAID0. You will get very good capacity and transfer rates for the money. I just hope you're not doing it over a network, even gigabit, because you'll find real fast that the gigabit network will limit your ability to move data beyond the network's actual throughput (not its theoretical throughput).
It would be easier if we knew what you were planing on doing, the size of the files, how they're transferred, where they're going, etc (not that you have to give personal details, but I think you get what I'm saying).
Very best,