Zap beat me to it in regards to the amps on the PSU unit. If you are running 2-3 powerful GPUs, they really start to tax the available amps on the rail. My 750 was struggling to provide enough amps to my 2 GTX 260s when they were overclocked (albeit considerably), but just managed at stock. The overall power wasn't getting anywhere close to 750w, but the PSU was struggling nonetheless. So the lesson is to pay attention to the amp needs AND the wattage needs and try to get a PSU that will be efficient with the expected load you will be placing it on.