Skoorb- once you recognize how to use it, it's wonderful. But it's going to take a little bit of effort first. When you see a pop up you want to kill...
1) right click on the yellow thing in your toolbar
2) select Add/Delete Popup and the program setup window will appear
3) double click the title of the offending pop-up from the bottom window- this adds it to the list of titles that POW will kill when it sees them in the top window
4) click Done. you won't see a pop-up with that title again.
Just takes some work at first, but it's reliable and works very well.