Fractal Design Midi ARC 2 - I run an offset 280x30x140 on top with 2 push fans and a 280x60x140 rad in front with 4 140 fans in push/pull - Nice Case and easy to Modify if need be ;o)
You will have 2 x's 5.25 bays usable for an Optic on top and say a RP 401x2 in the lower bay with 3 HDD + 1 SSD off set Bays. You can mount 2 more SSD's on the back but then your running out of Intel SATA Controllers.
Has been running at under 40C topping 68C after 3 years when benching on the worst of days ;o)
Bad PIC's but it's all there ;o)
I got about 50 lbs packed into a Fractal Midi R2
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ASUS P8Z68-V Pro Gen3 / i7 2700k-running at 4.8/ 16Gb Samsung MV-3V4G3D-US / CF 290X / 1 SSD and 3 WD Blacks. Optic Drive - WinTV and Intel Nic card.