...researchers often can't validate findings when they go back and run experiments again. Just last month, a team of researchers published the findings of a project to replicate 100 of psychology's biggest experiments. They were only able to replicate 39 ...
...researchers at Amgen were unable to reproduce 89 percent of landmark cancer research findings for potential drug targets...
When a press release confused correlation with causation, 81 percent of related news articles would, too. And when press releases made unwarranted inferences about animal studies, 86 percent of the journalistic coverage did, too...
Because of these now well-known problems, it's not unusual to hear statements like those from The Lancet editor Richard Horton that "Much of the scientific literature, perhaps half, may simply be untrue." He continued: "Afflicted by studies with small sample sizes, tiny effects, invalid exploratory analyses, and flagrant conflicts of interest, together with an obsession for pursuing fashionable trends of dubious importance, science has taken a turn towards darkness."
Long before it was mainstream to criticize science, Sheila Jasanoff, a Harvard professor, was arguing that science — and scientific facts — are socially constructed, shaped more by power, politics, and culture (the "prevailing paradigm") than by societal need or the pursuit of truth...