When Cloning Windows Hard Drive, if it is a legal installation, after cloning, Windows needs to be reactivated.
Many times reactivation problems occur at the Splash screen.
I do not know what you use for Ghosting, but Acronis True image and similar programs, when used correctly, Ghost perfectly to the last bit. Unless there is activation or other security issues concerning the info to the OS about the new Hard Drive nothing get messed up.
If the Cloned Drive is put on another computer with different chipset it getting messy.
Solving such a problem is long story and solutions can be found by Googling.
:sun: