Chances are that it'll perform like any other antenna of the type with the same gain figure, if it's a real concern, you should compare the radiation patterns of the antennas you are looking at. There are usually two "Smith charts" (grids on a circle) one represents the shape of the signal horizontally (an omni-directional antenna would be a circle), one represents the vertical pattern (like looking at the antenna from the side).
Keep in mind that passive gain (i.e., no amplifiers) is created by electrically gathering or redirecting signal from other parts of the pattern and concentrating them somewhere else. High gain omni antennas tend to have very narrow vertical coverage (less like a doughnut, more like a frisbee) and (design dependent) tilted somewhat skyward / toward the tip.
Placement can often be more critical than gain ... try putting a CD ~3" behind an omni to reflect some of the energy in the desired direction ... play with it, it might help.