My current setup is a e6750, HIS 3870, 2gb of ddr2 1066, and run at 1920x1200.
COD 4, POTBS, Unreal 3, and the demo of Sins of a Solar Empire all run perfect cranked up to max with no AA enabled. Crysis I bumped down to medium-high instead of all high and it's enjoyable though I do get an occasional stutter. I've only had this monitor for about 3 weeks. Before that, with the exact same hardware setup, running at 1280x1024 I ran with 2x or 4x AA enabled for the games I listed. In my opinion games look much better at 1920 with no AA compared to 1280 with 4x AA. It's worth the sacrifice.