Played this game through on it's release, and I keep coming back. I just started a new playthrough with YUP and the "Afterschool Special" mod. Seems very interesting, but I haven't completed the school mission though. If it does, what it says it does, I'll be very happy! (The school becomes your home and personal science/crafting lab)
I love Bethesda exploration games, and I really love the Fallout universe. FNV is one of the best games of all time, IHO. I loved FO3, but FNV is just more, bigger, better. Maybe FO3 had a slightly better atmosphere, but NV has so much more.
I can't wait to see FO4.