What kind of case? A really nice setup would be one blowhole feeding cool air into the cards and a second one feeding cool air to the CPU's intake area, you could do that with dual 80mm or 92mm fans on some cases. I have one case with a 120mm blowhole dead-center over the CPUs on a dual-P3 system. The other case has a dual-Celeron with a 120mm blowhole positioned so half the air is going into the upper cards and the other half is going over the top side of the AGP card to the CPUs (that's my gaming system at the moment).
On the first system, my goal was to cool down the CPUs, especially the rear one, and I tried the exhaust idea first, but the intake worked far better. You could get a Radio Shack digital thermometer and test both fan directions to see what helps most for your system.