I use them for stock trading and IRA, not for general banking. Some coworkers are using Ameritrade which looks to be more reliable and cheaper.
Maybe once or twice a week on e-trade parts of the site won't work, and it will ask you to log in when you try to go to those parts. The login will fail (because that site section is down) and increase your failed login count until it makes you close and reopen your browser before you can log in again.
Also when auto-reinvesting dividends in the IRA the date on the shares bought with dividends is shown as 1/1/1970 making me wonder why the shares haven't gone up much in 33 years....