Just speaking from my own personal experience, vaccines made all the difference. Earlier on in the pandemic, it helped that I lived in a community known for quality healthcare and a large pharma/biotech presence. That meant people here generally were more cautious and masks were everywhere. That helped me feel safer when it came to ordering takeout, going to the store and generally participating in the economy.
But my family still didn’t feel comfortable with out-of-state travel, air travel, hotel stays and such until we got vaccinated (and we’re still taking precautions because our kids are too young to be vaccinated atm.) Now we’re planning beach trips, getaways for the 2 of us, even potential coast to coast air travel in the next few months. Slowly getting back to normal, but vaccinations made it possible. I think my state is still only at 36% fully vaxxed and I’m hoping we can double that before back-to-school.