Let's look at 5 CPUs for a sec:
E2160 - $79; 9 multi x 200 FSB, 1mb cache
E2180 - $85; 10 multi x 200 FSB
E2200 - $95; 11 multi x 200 FSB
E4400 - $121; 10 multi x 200 FSB, 2mb cache
E4500 - $118; 11 multi x 200 FSB
Many of the E2XXX and E4XXX series top out around 370 - 380 FSB. Some can do more than 400. Avg max core speed OCed is ~ 3.1 - 3.2ghz +/- 200mhz. That means if you go with an E2200 or E4500 with the 11 multiplier, your FSB max will probably be ~ 300 b/c your chip would be running at 3.3ghz at that point. Now let's say you wanted to try and max your FSB and drop your multiplier to let's say 9x. Why then would you want to overpay for a E2200 when the E2160 will suffice? 9 x 370 = 3.33 ghz which is plenty fast and slightly above the avg overclock range for these CPUs.
IMO, if you are going to pay $95 (and higher at some retailers) for the E2200, you might as well pay another $23 and get the E4500 with double the L2 cache. Otherwise, put the extra $16 you save by going with the E2160 toward a better HSF like the $22 Arctic Cooling Freezer 7 Pro. That is the better trade overall.