Are you saying that a duplicator can be made to read six separate discs in one operation? That sounds wonderful!
There are endless configurations, you'd have to research. I can't imagine there isn't a multi bay optical disk duplicator out there with with ability to duplicate to HDD. You would need one with the ability to skip burning the duplicates and just leave ISOs on the internal HDD to do what I suggested.
Depending on how sensitive the data is, and if you have more than one copy of your stack of DVDs, you might consider outsourcing the job to a media distribution and duplication company. Send them discs, HDD, and a check for a few $100 bucks and 3 days later get your discs and full HDD back.
Not to promote any particular company, but this was the first relevant link in Google results:
http://www.proactionmedia.com/mfDigital-ripstation.html
Equipment looks costly for one time use, but the same company providing the equipment should also provide in house services as well. Then again, I hope you expected multi thousand dollar prices for this kind of gear in the first place if you were looking at a company purchase of a 1000 disc network attached auto loader.
Finally, at the very least, it looks like these stations can also be configured as jukeboxes, satisfying your original needs in your first post for a jukebox device.
Depending on your expected growth and continued use of optical media at your company, it would be a wise investment in equipment. Otherwise you should circumvent the need for optical media entirely and go with a ripping/duplication service for the initial 300 disc bulk rip, then convert your current infrastructure to be NAS HDD based from here on out. This would be best from a data handling and productivity stand point for the future of the company: more compact, centralized to a single vastly higher performance storage device, trivial backups involving two or more HDDs at 150 MB/sec, cheap, convenient, simultaneous 24/7 real time access by all users, no media handling or transport, no redundant copying of GB of data over the network, etc.
But if working with bulk optical media is one of the primary roles of your company and it simply can't be avoided, purchasing a in house rip station/duplicator/jukebox device is going to be essential for managing that many optical discs. For starters, mission critical data that only exists on optical disc should be re-burned every 5 years or so due to the high error rate and relatively short archive life of organic and bonded optical media.