On Intel® processors and Intel chipset based boards that have been released, the answer is that you can put in 1, 2 or some odd combo of sticks of memory on a triple channel boards and it will drop you down to a single channel mode. So it will hurt your performance but it won’t stop you from running your system. So on an X58 board if you put memory in like this it would try you down to a single channel mode.
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Christian Wood
Intel Enthusiast Team