False. I have done it many times. If you are worrying about disk alignment, that problem can easily be solved. What I do is use Acronis True Image 2010 and backup the drive to an image. Then, I would create the correct disk alignment for the SSD. Boot from Acronis disk and select recovery. Instead of recovering the whole disk from the image, select just the C drive and point it to the SSD partition you created. Make it active partition and you are set.