I played as a human noble on my first playthrough.
1) Pick only one weapon/power specialization and stick to it(like 2 handed, sword & shield, or dual weapons) it really doesn't pay to try to specialize in more than one.
2)Money is tight in the beginning of the game as well so don't waste your money on the tomes that increase your stats/powers.
3)Unless you are a rogue, always keep one rogue in your party or you will not be able to open many doors and chests.
4)Get the custom armor from Wade's as soon as possible as it is the uber-armor in the game and especially handy fighting the dragons.