Installed 2000 Pro on quad coreXeon X2 processors to make a simple test, the eight cores do fine as well, only two sockets, the license is OK. Windows 2000 is faster like a rocket compared to XP with eight cores. Intel was doing a demo here of their new Xeon, WOW !! In Linux and in 2000 it rocks.
But if you can, avoid limitations provided by Microsoft with their licensing model. Use Linux.