Just as with any current high-end video card, there's no reason why the Radeon wouldn't work with Diablo II, Half Life or Sacrifice if it's configured and installed properly. However, Team Fortess 2, Warcraft III and Red Faction are upcoming titles, so no one with the possible exception of their developer can say anything about them. However, being the most feature-rich of today's gaming cards - and one of the fastest - I cannot think of a reason why Radeon wouldn't work just wonderfully with aforementioned games.