Depends on how much amusement I can get from the drunk person...  If I'm not in the mood, then they better leave me alone... But, if I want to be amused, I can think of all sorts of things to do to drunk people...
btw.. next time you see someone really really, almost to the point of puking drunk, suggest the following:
Big thick fluffy pancakes, smothered in VINEGAR!  
Amazing how many of them think for about 10 seconds, make a gagging sound, then vomit.   It doesn't have the same effect on sober people though... just drunk people.