Great for client machines; if you live in the server world, do this at your own risk. There's a reason we have it enabled and don't let you flip a switch and turn it off.
I can guarantee that if I get a bugcheck case because someone had this turned off and updated a ton of stuff, it's going to the bottom of the list of things to work on.
If you need to turn it off for a specific file, just reboot into safe mode, copy the file you want into the system32 or system32\drivers folder, copy it into the dllcache folder, then reboot in normal mode.
We'll find the version in the folder that's not supposed to be there, then replace it with the version in the dllcache folder. You now have your updated file, and you did it without screwing WFP.