you NEED proper air/fuel ratio to avoid detonation (leaning out). Its very hard to tune a carb for the slope of fuel enrichment needed.
It's also very important to pull timing out as boost grows, too.
So even if you have a TPI injectors (one or two big injectors spraying into the intake manifold) with a computer. Its just umpteen times easier to tune.
but yes, i just saw a carb'd 302 stang with a charger on it the other day. Ran horribly rich.
Rich = poor gas mileage, and loss of power
Lean = great gas mileage, more power. But too lean (14:1 air/fuel) and you'll burn a hole in your piston, burn a valve, or detonate your pistons into pieces in a second or two.
Who'd want to spend several thousand on a motor and have it blow after one bad run?