[*]Use AOL AVS as your resident AV.
[*]Get rid of Windows Defender, Ad-Aware and Spybot since all 3 have horrible detection rates when it comes to the detection and removal of the latest malware.
[*]Add SUPERAntiSpyware free as your other on-demand scanner along with AVGAS & a-squared. Since they do not run real-time it doesn't hurt to have all 3.
[*]Spyware Blaster is fine since it is more of a prevention tool and not a scanner.
[*]You may also want to consider a free HIPS/Behavioral blocker such as
Cyberhawk (recently acquired by PC Tools).