No, I've never had a problem being left-handed. But then I use my right hand for the mouse, not my left, too. I'm pretty flexible on which hand I use for things. I throw with my left, except with a frisbee where I can use either. And my right hand is both bigger and stronger than my left. I'm a weird dichotomy, but I write and throw balls with my left, so I consider myself a leftie.