Multi and OP, refer to your motherboards manual (it is different for every motherboard). If you don't have it look it up on your manufacturer's site (they should have it in PDF form), as I'm too tired to do it for you 😉 but no, you can't run duel channel with one modual, it is physically impossible. If you have support for duel channel, then you need two identical sticks of RAM that support duel channel to run it.