In my experience, mounting hard drives in any orientation other than horizontally does kill them off faster. In particular, there are a couple of HPs with vertical hard drives in the office where I work part time. Those computers have all had 1-2 drive replacements in the time I've been there, none of the other machines have had any HDD issues. Granted, it could be because of some other quirk with those systems since they're all the same model, but I don't think so since I know for a fact that the drives don't run excessively hot.