Turns out the backplates are the same, in case anyone was curious. I was able to swap the coolers in a few minutes without taking out the motherboard.
Results of the upgrade:
i5 2500k at 4.3GHz (1.26v in CPU-Z)
Asus P8P67-M Pro
Fractal Define R3
Test - IBT (w AVX) Very High (10 runs)
Temps measured in HW Monitor (Hottest Core)
Noctua NH-U9B SE2 - 66*
Noctua NH-D14 - 59*
Not quite as dramatic as I was hoping for, but I suppose a 7 degree improvement is respectable. I'm currently running with only one exhaust, so I'm wondering if installing a fan in one of the top positions (currently sealed) might bring it down another degree or two.