I would recommend against thinking you would be able to run different processor speeds.
I have a Tyan Tiger MP (s2460), which originally ran in uni-processor mode with an Athlon 1500 MP. I finally got the money and ordered a 1500 XP from an online retailer. They "upgraded" me to a 1600 XP because they didn't have any more 1500s. When I tried to run the 1500 and 1600 together the board told me there was a speed mismatch and it would only run in uni-processor mode. I tried downgrading the bios to the oldest version possible, still didn't work. (I believe all the reviewers must have been using dev boards with very early bioses.)
Luckily, I was able to trade my Athlon 1500 MP for an Athlon 1600 XP from one of my friends at school. The boards cannot tell the difference between XPs and MPs. Now it runs perfectly at 2 x 1600 XP

)
BTW, My friend was able to over clock the 1500 MP (1.3GHz) to 1.6 GHz very easily and he's not using water-cooling. He thinks that with water cooling 1.8 GHz is possible.
- Mike