68-pin is LVD (low voltage differential). It's a 68-pin cable not unlike an IDE cable except a slightly different shape. 80-pin is what is known as SCA (single connector attachment) and is used for hot-swap trays in servers. You can use 80-pin devices without a hot swap tray by using an 80-to-68 pin converter. You'll find 80-pin drives are usually cheaper, but the converters will run $15 minimum.
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