Whenever I play a new game I immediately configure its keybindings on my Nostromo N52. This way I don't have to worry about whether it's WASD or something else, I always play the same way
ps: This is probably already clear but just in case, I want to emphasize that I didn't reconfigure the settings on the game itself, but instead I configured the keybindings on my N52 software, to have the buttons I *want* to hit to do whatever it is the game defaults to. Then of course I save the setting to a file so I only have to do this one time. This is very handy so if I play on a friend's computer or if I reinstall my OS and had to reinstall all my games, or if I build a new computer, all I needed to do is leave the settings in the game to default and load my N52 setup for that game, and I'm good to go.