I know of no issues with the Santa Cruz aside from the gameport not working on a nForce2 board (nVidia's fault, but I'll say it real quiet in these parenthesis so the fanboys don't get defensive).
Lot of people bought their Santa Cruz cards through Dell, heck pretty sure that's where I got mine. I just use the regular drivers from turtlebeach.com without problems. Not sure if there are OEM versions of the SC or not though, and if there are what the differences are. So consider this a *bump* in that regard. If it's the same as the retail SC, no issues, enjoy.