Don't defrag automatically, or while SSD caching is enabled.
Thankfully enabling and disabling SSD caching takes all of 5 seconds.
Disable SSD caching, defrag, re-enable SSD caching.
It won't speed up anything that has already been cached, but might help for those times when it has to hit the HDD. Note that when you disable and re-enable the cache, the cache will have to be rebuilt at that point. That means the first boot afterwards and the first time launching games, etc will be slower until the cache is rebuilt.