Single side uses half the number of ram chips than double side, since it's newer and bigger (256Mbit vs 128Mbit or 512Mbit vs 256Mbit, and so on) memory chips so better performance and stability.
Many motherboards have 3 slots, but the chipset (such as 845) only supports 4 banks, so if you put in 2 double side, the last slot is useless.
Or like BX chipset supports 6 banks, some motherboards have 4 slots, the last slot is also useless if you put in 3 double side.
The only drawback of single side is your motherboard chipset could be too old that doesn't support the newer bigger size memory chips, like BX only supports up to 128Mbit chips, so only can use double side 256MByte module, not single side 256MByte module.