More thoughts to come this weekend, but I've already swapped to a different palm rest and tweaked my thumb-rest depth and tilt. I've also set up my basic windows button "mode" (including volume on the horizontal scroll wheel and buttons for ESC, end, home, back, forward, F5, DEL, copy and paste, with buttons to spare) and "modes" for Skyrim and Amalur, all within a single profile. This thing is a modder's wet dream from a hardware AND a software perspective. 78 assignable buttons per profile (6 "modes" with 13 programmable buttons each). And you can save infinite profiles and change them on the fly with 2 clicks (one on the taskbar icon, one on the profile of choice). No onboard memory, so you can't take your profiles with you, but you can email yourself the files if you know you'll be using the mouse elsewhere. More details and pics to follow.