if it's analog, don't count on it...
the high end analogs are good, but if you're going high end analog, you might as well go for digital connectivity, that is, if your soundcard can fully support it
I think that if you can get a surround home theater with digital, running from your soundcard, and with a nice Xplod sub(s)? it's better than any PC speakers you'll find in the market. but of course, that's my opinion.
at any rate, don't get creative speakers at mainstream, they suck. 
Altec Lansing XA3021 are the best mid range 2.1's (extremely, very Xtremly low distortion with bass and sound/audio clarity) = A+ for price and performance.
You'll find some bad reviews on these, but from a trance mixer like me, you've got one of the best here, XA3021.